Pathophysiology of human mitochondrial tRNA metabolism

Physiopathologie du métabolisme de l'ARNt dans la mitochondrie humaine

Jian-Hui Zhang (1) , Gilbert Eriani (2) , Xiao-Long Zhou (1)

1 UCAS - University of Chinese Academy of Sciences [Beijing]
2 ARN - Architecture et Réactivité de l'ARN

Mitochondria play multiple critical roles in cellular activity. In particular, mitochondrial translation is pivotal in the regulation of mitochondrial and cellular homeostasis. In this forum article we discuss human mitochondrial tRNA metabolism and highlight its tight connection with various mitochondrial diseases caused by mutations in aminoacyl-tRNA synthetases, tRNAs, and tRNA-modifying enzymes.

Mots clés: tRNA aminoacylation; tRNA modopathies; human mitochondria; tRNA induced pathologies

Domaines: Organisation et fonctions cellulaires [q-bio.SC]; Endocrinologie et métabolisme

Jian-Hui Zhang, Gilbert Eriani, Xiao-Long Zhou. Pathophysiology of human mitochondrial tRNA metabolism. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism , 2024, 35 (4), pp.285-289. ⟨10.1016/j.tem.2024.01.002⟩. ⟨hal-04567592⟩